
From a clinical standpoint, the regional EEG activity may represent a target for brain stimulation techniques to reduce SO latency and sleep fragmentation. Older adults showed a generalized reduction of delta power and delta/beta ratio in both pre- and post-SO intervals compared to young adults. The results point to several peculiarities in the elderly: (a) the generalized post-SO power increase in the slowest frequencies did not include the 7 Hz bin (b) the alpha power revealed a frequency-specific pattern of post-SO modifications (c) the sigma activity exhibited only a slight post-SO increase, and its highest bins showed a frontotemporal power decrease. Moreover, we compared the delta activity and delta/beta ratio between the older participants and a group of young adults. The topography of the 1 Hz bins’ EEG power and the time course of the EEG frequency bands were assessed.

The present study aimed to assess the topographical and temporal features of the EEG during the sleep onset (SO) in a group of 36 older participants (59–81 years). However, the spatiotemporal EEG pattern of the wake-sleep transition has never been described in the elderly. Healthy aging is characterized by macrostructural sleep changes and alterations of regional electroencephalographic (EEG) sleep features. Authors may use MDPI'sĮnglish editing service prior to publication or during author revisions. Submitted papers should be well formatted and use good English. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Please visit the Instructions for Authors page before submitting a manuscript. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. All manuscripts are thoroughly refereed through a single-blind peer-review process. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Research articles, review articles as well as short communications are invited. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. All submissions that pass pre-check are peer-reviewed. Manuscripts can be submitted until the deadline. Once you are registered, click here to go to the submission form. Manuscripts should be submitted online at by registering and logging in to this website. We invite authors and research groups to submit original researches, review articles and commentaries on these topics for this Special Issue.

Role of sleep hallmarks as possible biomarkers for pathological aging.Association of sleep features with normal and altered daily functioning in the elderly.Sleep disorders in healthy aging and age-related neurodegenerative diseases.Sleep pattern changes in healthy and pathological aging.Specifically, our aim is to attract research articles concerning the following research topics: The present Special Issue is focused on the sleep patterns observable in heatlhy and pathological aging. As our aging population is progressively growing, it is crucial to expand knowledge about the relation between sleep, normal aging, and age-related pathological conditions. The possible role of specific sleep features as biomarkers of pathological aging has been higlighted, and a bidirectional role between sleep alterations and cognitive decline in neurodegenerative diseases has been proposed.

Moreover, a growing body of evidence shows that singificant sleep alterations characterize many age-related pathological conditions. Healthy aging involves large sleep changes associated with modifications in sleepiness, cognitive functioning, and cardiovascular problems.
